List of 120 plant species that were extracted with methanol to determine quantitative antioxidant activity in order to select 31. In vitro antimutagenic activity of eclipta alba using ames test dissertation submitted to the tamiladu dr. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Studies on the antimutagenic activity of ascorbic acid in. Pdf evaluation of the antimutagenic and anticarcinogenic. To the best of our knowledge, this is the first report on the antimutagenic activity of r. Some of these compounds could be selected for further anticancer studies. Medical university in partial fulfillment of the regulations for the award of the degree of m. Dose dependent antimutagenic activity of the extracts is also evident from linear regression analysis of the data. The maximal decrease in the revertant numbers was found when the figure 1. Request pdf antimutagenic activity of turmeric extract beverages objective. Mutageneic and antimutagenic effects of some plant. Increase of single break repair by rejoining and induction of genes related to base and nucleotide excision. Antimutagenic and anticarcinogenic activity of tea polyphenols.
Antimutagenic and antioxidantprooxidant activity of. Pdf evaluation of the antimutagenic activity and mode of. Antimutagenic activity of the dte was carried out in two different strains of salmonella typhimurium. Studies about antimutagenic activities of fermented foods miso, pito, nai ge da have shown that microorganisms isolated from these foods have higher antimutagenic activities. Antioxidant and antimutagenic activities of bark extract. Three extracts were prepared from the leaves of accacia. If the inline pdf is not rendering correctly, you can download the pdf file here. Pdf invitro antioxidant, antimutagenic and cancer cell. To identify the antimutagenic component, the antimutagenic activity against mnu was compared among aqueous and methanol extracts fig. Pdf antimutagenic activity of olive leaf aqueous extract by ames. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens, although not always necessarily so. There are different classes of secondary metabolites present in the plants exhibiting antimutagenic activities. Graduate thesis or dissertation antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo public deposited. The antimutagenic activity of two plants maytenus ilicifolia and peltastes peltatus, both rich in compounds of the flavonoid and tannin groups and frequently.
Antimutagenic activity, % concentration, mgplate leaves rhizomes 8 9 28 28 63 75 0 10 20 30 40 50 60 70 80 90 0. Antimutagenic activity of alkylresorcinols from cereal grains the effect was the strongest in the case of indirectacting mutagens, benzo a pyrene and 2aminofluorene. Firdous, ramnath viswanathan and ramadasan kuttan affiliation. In vitro antioxidant and antimutagenic activities of different solvent. Antimutagenic activity of alkylresorcinols from cereal. Antimutagenic and mutagenic potentials of chinese radish. Biological activities for extracts of clavillia mirabilis. However, further studies to define the relationship between exposure to.
Molecules free fulltext antioxidant and antimutagenic. Antioxidant, mutagenic, and antimutagenic activity of frozen fruits article pdf available in journal of medicinal food 111. The alta has shown potent antioxidant activity with ec50 of 2. Fenugreek alkaloids was found to be more effective than parsley oil in this respect. The results showed that a significant antimutagenic effect of the extract was detected with both oxidative mutagens used figure 1. The mutagenic, antimutagenic and antioxidant properties of. Chemotherapeutic drugs have high toxicity associated with undesirable sideeffects. Dc article pdf available in acta poloniae pharmaceutica 633. Antimutagenic and antioxidant activity of the extract from belamcanda chinensis l. Pdf methanolic extracts of acorus calamus rhizome, hemidesmus indicus stem, holarrhena antidysenterica bark and plumbago. The study reveals the strong antioxidant and antimutagenic activity of r. Isolation and antimutagenic activity of some flavanone.
Found to perform antimutagenic activity through the increase of ogg1 expression, which is an enzyme responsible to remove 8oxoguanine a mutagenic product created after cells exposure to oxidative stress. Identification of the main component from the antimutagenic fractions. Pdf antimutagenic activity of methanolic extracts of four ayurvedic. The correlation between antimutagenic activity and total. Evaluation of the mutagenic andor antimutagenic activity. Antimutagenic activity of vinoserae extract in ames test without metabolic activation, strain ta102. These flavonoids have been reported to have anticancer activity 3639, and the antimutagenic activity was considered to contribute to their anticancer activity.
In vitro antioxidant activity of quercetin was better than ascorbic acid in all the test systems used. In the case of directacting mutagens, daunorubicin and methyl methanesulfonate, the diminution of the mutagenic activity by the alkylresorcinols was smaller but still noticeable. It is used in the popular medicine for the syphilis treatment, diaphoresis, inflammations etc. Detection of the antimutagenic activity of the vinoserae extract was carried out using the ames test with salmonella typhimurium his. The study indicated that the antimutagenic activity of quercetin was not solely accountable by its antioxidant nature. New fluphenazine analogue with antimutagenic and anti. T14099 branches mexico antimutagenic activity hot h2o ext not stated 3. It is also used as a foodcoloring agent and known as natural green 3, and it has the e number e141.
Suppression of error prone pathway is responsible for. The correlation between antimutagenic activity and total phenolic content of extracts of 31 plant species with high. In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually dna, of an organism and thus increases the frequency of mutations above the natural background level. In this study, the antimutagenic and anticancer effect of darjeeling tea extract dte has been evaluated. New fluphenazine analogue with antimutagenic and antimultidrug resistance activitydegradation profile and stabilityindicating method agnieszka sobczak 0 1 2 artur tezyk 0 1 2 joanna szyndlarewicz 0 1 2 jan ziarniak 0 1 2 piotr swiatek 0 1 2 wieslaw malinka 0 1 2 0 department of chemistry of drugs, wroclaw medical university, 211 borowska str. In this study, antimutagenic activity of an ethanol extract of rhaphidophora pinnata leaves was evaluated by. A comparison of the antimutagenic potential of green, black and decaffeinated teas. Acorus calamus, antimutagenic activity, hemidesmus indicus, holarrhena antidysenterica, medicinal plants. As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold. The antimutagenic activity of the three compounds were determined in the ames test using salmonella typhimurium ta98, ta100 and ta102. Study of antimutagenic potential of phytoconstituents isolated from.
This article is from annals of clinical microbiology and antimicrobials, volume 10. The possibility that ascorbic acid, as a nucleophile, may in hibit mutagenicity induced by electrophilic metabolites of nnitroso compounds was exam. The antimutagenic activity was congruent with a high antioxidant activity that could promote the dna repair system. There was a direct correlation between the presence of antioxidant activity and antimutagenic activity of the plant extracts. The correlation between antimutagenic activity and total phenolic. Antimutagenic activities of some foods, journal of the. There is increasing evidence that cancer and other mutationrelated diseases can be prevented by intake of dna protective agents. The antioxidant activity of the three compounds were determined by the quantitative 2,2diphenyl1picrylhydrazyl dpph free radical scavenging method. The results indicate that investigating antioxidant activity and the number of antioxidant compounds in plant extracts could be a viable option in searching for antimutagenic compounds in plants. Hydroxyl radicalscavenging activity of the flavonoids derived from s.
The importance of free radicals and catalytic metal ions in human diseases. Antioxidant and antimutagenic potential of extracts of. Abstract the antimutagenic activity of spearmint mentha spicata, a popular food flavoring agent, was studied in the salmonella assay. The over all antimutagenic potential of above four extracts was found to be in order of a. Antibacterial and antimutagenic activities of novel zerumbone analogues s. Antimutagenic and anticancer activity of darjeeling tea in.
All mutagens have characteristic mutational signatures with some. Chemical and physical properties of chlorophyll need to be determined in order to reduce its loss during food processing and storage. Supporting information structures and antimutagenic. Marked antimutagenic potential of aqueous green tea. Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. Antimutagenic activity of lutein an oxycarotenoid present. Antibacterial and antimutagenic activities of novel.
Apparatus uv and ir spectra were measured with varian cary 100 conc andshimadzu8300ftir,respectively. Full text get a printable copy pdf file of the complete article 923k, or click on a page image below to browse page by page. This study investigates for the first time the antioxidant, mutagenic and antimutagenic activity of an ethanol extract of h. Pdf antioxidant, mutagenic, and antimutagenic activity. Table 2 shows the differential antimutagenic activity of honey against uv and gamma induced mutagenesis in e. Antimutagenic and dna damage protective activities of a. The identification of antimutagenic agents present in plants presents an effective strategy to inhibit pathogenic processes resulting from exposure to. The heart shaped of piper betle leaves are initiate in ancient sanskrit texts, include. Evaluation of antioxidant activities and antimutagenicity.
Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. The fluorine substitution changed the antimutagenic signature of bichalcophenes. The mutagenic and antimutagenic activities of hexane, chloroform, ethyl acetate and methanol extracts from leaves of myrtus communis, were investigated by. In addition, the antimutagenic activity toward aflatoxin b1 may be partly due to the inhibition of enzymes necessary for activation of this mutagen. The antimutagenic activities of the cell bodies of several lab isolated from kimchi were studied using the ames test and the sos chromo test son et al. Graduate thesis or dissertation antimutagenic potency of. Dorota woeniaka, jan oszmiaskib and adam matkowskia adepartment of pharmaceutical biology and botany, medical university in wroc. This study was conducted to investigate the potential of turmeric extract.
The antioxidant effects of turmeric oil and its fractions may provide an explanation for their antimutagenic action. Antioxidant and antimutagenic activities of different. Antioxidant and antimutagenic activity of curcuma caesia roxb. Antioxidant, antimutagenic and cytotoxic properties of. The present study was designed to detect the mutagenic effects of vincristine vcr anticancer drug and antimutagenic effects of some. Antimutagenic properties of fenugreek alkaloids and. Antimutagenic activity an overview sciencedirect topics. Honey of either brand was not found to affect the background rif r frequency and hence considered to be nonmutagenic in this assay system. Antimutagenic components in spatholobus suberectus dunn. Darjeeling tea, a most popular variety of black tea, though consumed by the people in different parts of world but its beneficial health effects have not been investigated in details. In addition, antimutagenic and antigenotoxic effects evaluated by micronucleus and the comet test showed that extracts of shiitake have a antigenotoxic and antimutagenic activity 52 in vivo 53. However, in vitro free radical scavenging activity of quercetin correlated well with the antimutagenic activity. Review study on potential activity of piper betle abstract piper betle is glorified as evergreen and perennial plant that god designed and have given the shape of his own heart.
In fact, the tested extracts are the complex mixtures of several compounds, particularly phenolic compounds which have diverse chemical structures that determine various properties. The antimutagenic activity of both the extracts was evaluated against sodium azide, 4nitroophenylenediamine and 2aminofluorene mutagens in ta98 and ta. Antimutagenic activity of methanolic extracts of four. Antiformation and antimutagenic activities of extracts. Antimutagenic activity of turmeric extract beverages request pdf. File scanned at 300 ppi monochrome using capture perfect 3. The antimutagenic activity has been assayed in the antimutagenic and antioxidant activity of the extract from belamcanda chinensis l. This present research highlight the phytochemical profile, the antioxidant, the antimicrobial, the antimutagenic and the antiproliferative activities of an essential oil extracted from corchorus olitorius l. Many substances with antimutagenic activity have been found by several investigators soudamini et al.
Tea catechins and crude extracts, however, have some beneficial effects on human health, such as suppression of a rise in blood pressure. The antimutagenic activity showed that all of the extracts exhibited strong inhibition especially the ethanol extract of p. Antimutagenic activity of spearmint yu 2004 environmental and. Antimutagenic activity was evaluated using micronucleus test in mice. Pdf abstract medicinal plants are an important source of substances which are claimed to induce antiinflammatory and antioxidant effects. Pdf the incidence of colorectal cancer is growing worldwide. Our study is based on 3 assays that are widely used to evaluate.
Amala cancer research centre, amala nagar, thrissur, kerala680 555, india. Antimutagenic activity of extracts of natural substances in the. Antimutagenic activity of lutein an oxycarotenoid present in the macula and its inhibition of cytochrome p 450 enzymes in vitro volume. Evaluation of antimutagenic activity and mechanisms of action of. The antimutagenic effect of compounds can be evaluated on the basis of their ability to inhibit mutagens mutagenicity 4143.
561 395 1072 617 1197 438 1362 1446 119 963 1302 1044 1074 1540 685 1315 290 1465 1533 995 1369 554 1193 14 1239 1174 1433 648 303 347 1424 619 872